tuberculosis isolates from China, Mongolia, Hong Kong, the Philippines, Korea, Thailand, Malaysia, and Vietnam. We used an IS 6110 probe for the initial screening of M. IS 6110 provides the most variable patterns yet discovered when it is used as a probe for RFLP analysis for the subdivision of M. tuberculosis provides a versatile tool for the identification of transmission ( 25, 28), the investigation of TB outbreaks ( 11, 17), the distinction between reactivation and reinfection ( 26), as well as proof of laboratory cross-contamination ( 1, 2, 6). tuberculosis isolates from each country had comparatively similar characteristics depending on the classification factor, each country's isolates showed characteristic DNA fingerprints and differed slightly from the isolates from the other countries in either the mode number of IS 6110 copies or the distribution of IS 1081types.ДNA fingerprinting of M.

A 1.3-kb single-copy IS 6110 fragment was found only in Vietnamese M. One IS 1081 type was present in 56% of Filipino isolates, had a specific 6.6-kb PvuII fragment in its IS 6110 DNA fingerprint, and was termed the вЂњFilipino family.вЂќ The IS 1081 types of Thai isolates had interposing characteristics between the characteristics of northeastern Asian and southeastern Asian IS 1081 types. We found a number of novel IS 1081types in this study. Chinese, Mongolian, Hong Kong, Filipino, and Korean isolates had comparatively more copies of IS 6110 (proportion with eight or more copies 95% В± 5%), while Thai, Malaysian, and Vietnamese isolates had fewer copies (proportion with eight or more copies, 60% В± 4%). A total of 422 Mycobacterium tuberculosis isolates from eight countries were subjected to IS 6110 and IS 1081 DNA fingerprinting by means of restriction fragment analysis to characterize M.

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